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Home Urine Test Measures Insulin Production in Diabetes

Date: 2.3.2011 

A simple home urine test has been developed which can measure if patients with Type 1 and Type 2 diabetes are producing their own insulin. The urine test replaces multiple blood tests in hospital and can be sent by post as it is stable for up to three days at room temperature. Avoiding blood tests will be a particular advantage for children.

The urine test measures if patients are still making their own insulin even if they take insulin injections. Researchers have shown that the test can be used to differentiate Type 1 diabetes from Type 2 diabetes and rare genetic forms of diabetes. Making the correct diagnosis can result in important changes in treatment and the discontinuation of insulin in some cases.




R. E. J. Besser, M. H. Shepherd, T. J. McDonald, B. M. Shields, B. A. Knight, S. Ellard, A. T. Hattersley. Urinary C-Peptide Creatinine Ratio Is a Practical Outpatient Tool for Identifying Hepatocyte Nuclear Factor 1- /Hepatocyte Nuclear Factor 4-  Maturity-Onset Diabetes of the Young From Long-Duration Type 1 Diabetes. Diabetes Care, 2011; 34 (2): 286 DOI: 10.2337/dc10-1293

A. G. Jones, R. E. J. Besser, T. J. McDonald, B. M. Shields, S. V. Hope, P. Bowman, R. A. Oram, B. A. Knight, A. T. Hattersley. Urine C-peptide creatinine ratio is an alternative to stimulated serum C-peptide measurement in late-onset, insulin-treated diabetes. Diabetic Medicine, 2011; DOI: 10.1111/j.1464-5491.2011.03272.x




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