Home pagePress monitoringHow Salmonella Bacteria Spread in Humans

How Salmonella Bacteria Spread in Humans

Date: 3.11.2010 

 

New findings by National Institutes of Health scientists could explain how Salmonella bacteria, a common cause of food poisoning, efficiently spread in people.

Epithelial cells line the outer and inner surfaces of the body, such as the skin and gut, and form a continuous protective tissue against infection. But Salmonella have learned how to live inside epithelial cells and use them for their benefit. Salmonella protect themselves within special membrane-bound compartments, called vacuoles, inside gut epithelial cells.

Using special high-resolution microscopes to view laboratory-grown human intestinal epithelial cells and laboratory mice infected with Salmonella discovered a secondary population of Salmonella not confined within a vacuole, but instead moving freely inside the epithelial cells. This reservoir of Salmonella is distinct from vacuolar Salmonella. The bacteria multiply much faster; they have long tail-like projections, called flagella, used to move; and they exhibit a needle complex they use to pierce cells and inject their proteins. With these attributes, this population of Salmonella is genetically programmed to invade new cells.

Original Paper:

L. A. Knodler, B. A. Vallance, J. Celli, S. Winfree, B. Hansen, M. Montero, O. Steele-Mortimer. Dissemination of invasive Salmonella via bacterial-induced extrusion of mucosal epithelia. Proceedings of the National Academy of Sciences, 2010; DOI: 10.1073/pnas.1006098107

Source:

http://www.niaid.nih.gov/news/newsreleases/2010/Pages/Salmonella.aspx

 


 

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