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Novel Drug Shows Potential For Treating Leukemia

Date: 23.4.2007 

Researchers from the Children's Cancer Hospital at The University of Texas M. D. Anderson Cancer Center have found that a novel targeted therapy effectively treats acute leukemia in animal models by preventing cancer cells from being purged of damaged proteins. In the March online issue of the journal Blood, investigators reported that the new proteasome inhibitor, NPI-0052, not only successfully kills leukemia cells, but also shows greater efficacy than its predecessor bortezomib when combined with other agents in animal models. According to researchers, proteasomes clean out mutated or damaged proteins within cells, which promotes cell growth and allows cancer cells to rapidly reproduce. Proteasome inhibitors block this process, resulting in apoptosis, or cell death, of the malignant cells.... Whole article on "ScienceDaily":[ www.sciencedaily.com]

Cheap molecule may attack tumors - A cheaply-produced molecule may be the key to treating a variety of cancers, claim Canadian researchers (23.4.2007)

Researchers Develop New Method For Fighting Leukemia - Researchers at Virginia Commonwealth University's Massey Cancer Center have created a new method to improve the antileukemic activity of a novel agent that triggers programmed cell death, a development that could lead to more effective strategies for fighting leukemia and other malignancies (18.1.2007)

Leukemia drug Gleevec may damage heart: study - The study, published Sunday in the online edition of the journal Nature Medicine, followed by reports that 10 patients taking Gleevec for chronic myelogenous leukemia developed severe congestive heart failure (9.8.2006)

The use of quantitative assessment of Wilms tumour gene 1 for monitoring of residual disease in acute myeloid leukemia patients - Polak J, Markova J, Schwarz J, Maaloufova J, Volkova Z, Cermak J, Haskovec C (2.6.2006)

Touch-down reverse transcriptase-PCR detection of IgV(H) rearrangement and Sybr-Green-based real-time RT-PCR quantitation of minimal residual disease in patients with chronic lymphocytic leukemia. - Institute of Hematology and Blood Transfusion, Prague, Czech RepublicInstitute of Molecular Genetics, Academy of Sciences of the Czech Republic, Prague, Czech Republic (17.3.2006)




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