Home pagePress monitoringOnce-a-week insulin bolstered by results of phase 2...

Once-a-week insulin bolstered by results of phase 2 clinical trials

Date: 19.4.2021 

For millions of patients with diabetes, daily insulin injections are a necessary nuisance. A once-a-week shot might be more palatable, and new results from phase 2 clinical trials suggest just such a drug is safe and effective.

Kredit: Mr Hyde / Wikimedia Commons.The drug at the heart of the studies is called icodec, an insulin analog with a half-life of 196 hours – a little over eight days. Developed by Novo Nordisk, the drug works by modifying the insulin molecule to keep it from being broken down by enzymes, and maintains a steady insulin release by binding to proteins produced in the liver.

Back in September 2020, the results of a phase 2 trial of icodec were released, showing that the weekly shot was just as effective at managing patients’ blood sugar levels as the usual daily doses, and had similar numbers of adverse events. The two new studies support this finding.

“A weekly insulin is a game-changer that will decrease the treatment burden for patients while also improving compliance,” says Ildiko Lingvay, an author of both studies. “This treatment will also decrease the burden on those who care for patients with diabetes requiring insulin. For example, for patients who need help injecting, those living in long-term care facilities, and those with memory problems, a once-weekly insulin will facilitate treatment and decrease the burden on the care providers.”

A large phase 3 clinical trial is already underway, which will evaluate the efficacy of weekly icodec doses in patients with either Type 1 or Type 2 diabetes.





  • BC AV CR
  • Budvar
  • CAVD
  • CZBA
  • Eco Tend
  • Envisan Gem
  • Gentrend
  • JAIP
  • Jihočeská univerzita
  • Madeta
  • Forestina