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Post-doc position in cell biology at Charles University

Date: 19.4.2012 

Postdoctoral position is available to study the regulation of splicing and the interplay between transcription and pre-mRNA processing in yeast. Candidates should be interested in the molecular mechanisms of gene expression regulation and should have experience in molecular genetics, biochemistry, RNA analyses and cell biology/microbiology.

The Laboratory is interested in the mechanisms of splicing regulation and the relationship between splicing and transcription using yeasts as model organisms. Both Saccharomyces cerevisiae and Schizosaccharomyces pombe are used to study evolutionarily conserved regulatory factors of the synthesis and maturation phases of transcript production. Introns in S. cerevisiae are relatively few and short; the spliceosomes still contain an almost complete array of splicing factors as compared to other organisms (S. pombe or higher eukaryotes). The study of splicing factors in an organism with reduced intronome should help to identify interactions that link splicing to other gene expression processes.

Potential aims include:

  • Regulation of RNA helicases during the splicing cycle
  • Factors and molecular mechanisms of coupling of transcription initiation, elongation, and splicing
  • Mechanisms that coordinate transcript production& maturation with cell cycle progression
  • Role and regulation of cyclophilins in the spliceosome of S. pombe

Additional information on this position and research of the group may be obtained from Petr Folk (postdoc@natur.cuni.cz).

Applicants should have a recent Ph.D. in the corresponding field and a promising publication record; the degree had to be obtained no earlier than on 28 March 2008. Successful candidates will be required to teach in advanced courses related to their specific area of expertise. The courses, aimed at Ph.D. and M.Sc. students, will be held in English and will be organized as intensive courses/workshops at various institutions outside of Prague. The teaching workload will not exceed five hrs/average week.

The positions will initially be for 33 months and will be funded through the European Social Fund in the Czech Republic. Funds for long-term research stay (up to 6 months)/international mobility are provided. The salaries will start at 40K CZK per month. The Faculty will hold a competitive selection; official call for application will be announced in early 2012. There will be a trial period of two months.



Department of Cell Biology
Charles University in Prague
Faculty of Science
Viničná 7, 128 43 Praha 2





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