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Study: Viral infection in nose can trigger middle ear infection

Date: 16.9.2014 

The study is published in the current online issue of the American Society for Microbiology's journal Infection and Immunity.

"Every individual has bacteria in the nose that most of the time doesn't cause problems," said the study's lead author, W. Edward Swords, Ph.D., professor of microbiology and immunology at Wake Forest Baptist. "However, under certain conditions those bacteria can migrate to the middle ear and cause an ear infection, and now we have a better understanding of how and why that happens."

The bacterium used in the animal study, Streptococcus pneumoniae, is known to exist in the noses of children in two phases, one relatively invasive and the other relatively benign. The more invasive phase is more frequently found in the infected ears of children. However, the study indicated that the flu virus promoted bacterial growth and ear infection regardless of which phase of the bacterium was present in the nose.

"These findings suggest that a flu infection modifies the response of the immune system to this particular bacterium, enabling even the type that has previously been considered benign to infect the middle ear," Swords said.

Author: Marguerite Beck, Wake Forest Baptist Medical Center

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Work in Swords' laboratory is sponsored by NIH Institute of Deafness and Other Communication Diseases grant R01 DC10051 and AstraZeneca.

Co-authors of the study are John T. Wren, B.S., Lance A. Blevins, B.S., Bing Pang, Ph.D., Lauren B. King, Ph.D., Antonia C. Perez, Ph.D., Kyle A. Murrah, Ph.D., Jennifer L. Reimche, B.S., and Martha A. Alexander-Miller, Ph.D., all of Wake Forest Baptist.




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