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Cheap molecule may attack tumors

Date: 23.4.2007 

A cheaply-produced molecule may be the key to treating a variety of cancers, claim Canadian researchers. Dicholoroacetate (DCA) has been suggested for years as a possible treatment for certain rare metabolic disorders in children. The University of Alberta team, writing in the journal Cancer Cell, now say it could encourage cancer cells to die. Experts say much more research will be needed before an effective cancer treatment can emerge... Whole article on"news.bbc.co.uk":[ http://news.bbc.co.uk/2/hi/health/6576655.stm]

Short chromosomes put cancer cells in forced rest - A Johns Hopkins team has stopped in its tracks a form of blood cancer in mice by engineering and inactivating an enzyme, telomerase, thereby shortening the ends of chromosomes, called telomeres "Normally, when telomeres get critically short, the cell commits suicide as a means of protecting the body," says Carol Greider, Ph In an unusual set of experiments, the research team first mated mice with nonoperating telomerase to mice carrying a mutation that predisposed them to Burkitt’s lymphoma, a rare but aggressive cancer of white blood cells Whole article: http://www (27.4.2007)

Novel Drug Shows Potential For Treating Leukemia - Researchers from the Children's Cancer Hospital at The University of Texas M In the March online issue of the journal Blood, investigators reported that the new proteasome inhibitor, NPI-0052, not only successfully kills leukemia cells, but also shows greater efficacy than its predecessor bortezomib when combined with other agents in animal models According to researchers, proteasomes clean out mutated or damaged proteins within cells, which promotes cell growth and allows cancer cells to rapidly reproduce Whole article on ScienceDaily (23.4.2007)

Genes Associated With Adverse Reactions To Cancer Radiotherapy Treatment Identified - Medical scientists at the University of Leicester have announced a potentially unique advance in breast cancer research by identifying two genes associated with adverse reaction to cancer treatment The research could mean people who might react badly to radiotherapy could be warned in advance or alternative treatments be sought The team who carried out the study included Drs Paul Symonds, Mark Plumb, Irene Peat and George Giotopoulos of the Department of Cancer Studies and Molecular Medicine and the Department of Genetics at the University of Leicester Whole article on ScienceDaily (21.4.2007)

Scientists Stop Genes that Help Breast Cancer to Spread - US scientists have demonstrated a way to stop breast cancer spreading to other parts of the body by either switching off the genes involved or blocking them with drugs Tumours formed from cancer that has spread or metastased from the primary site to other parts of the body cause 90 per cent of cancer deaths The process of metastasis or cancer spread is still much of a mystery to scientists Dr Joan Massagué from the Memorial Sloan-Kettering Cancer Center in New York, US, has been working in this field for some time Whole article www (13.4.2007)

Cell Biology: New Connection Between Cancer and Sugars - Every cell in the human body is controlled by signaling networks that are responsive to external stimuli Most of the important proteins that decorate the outside of human cells have complex sugars attached to them "Our research shows that the sugar composition of these receptor proteins controlled the amount of time the protein was available to interact with the external messages, in effect, changing the likelihood that a receptor could be activated," states Dr Whole article www (11.4.2007)

 

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