Date: 16.5.2007
Controlling Damaging Protein Plaques Without Side-effects: Research Could Improve Alzheimer's Medication - When protein plaque builds up in the blood, it can result in serious diseases such as heart disease and Alzheimer's Researchers in the International Institute of Nano and Molecular Medicine at the University of Missouri-Columbia are studying the possible use of carboranes, which are clusters of boron and carbon atoms, to prevent such side effects COX activity is seen in common nonsteroidal anti-inflammatory drugs like aspirin and ibuprofen The protein transythyretin acts as a shuttle to transport thyroxine, a hormone, throughout the body Whole article: http://www (27.4.2007)
Short chromosomes put cancer cells in forced rest - A Johns Hopkins team has stopped in its tracks a form of blood cancer in mice by engineering and inactivating an enzyme, telomerase, thereby shortening the ends of chromosomes, called telomeres "Normally, when telomeres get critically short, the cell commits suicide as a means of protecting the body," says Carol Greider, Ph In an unusual set of experiments, the research team first mated mice with nonoperating telomerase to mice carrying a mutation that predisposed them to Burkitt’s lymphoma, a rare but aggressive cancer of white blood cells Whole article: http://www (27.4.2007)
Hepatitis C virus production by human hepatocytes dependent on assembly and secretion of very low-density lipoproteins - Hepatitis C virus (HCV) and triglyceride-rich very low-density lipoproteins (VLDLs) both are secreted uniquely by hepatocytes and circulate in blood in a complex These vesicles, which contain the HCV replication complex, are highly enriched in proteins required for VLDL assembly, including apolipoprotein B (apoB), apoE, and microsomal triglyceride transfer protein In hepatoma cells that constitutively produce infectious HCV, HCV production is reduced by two agents that block VLDL assembly: an inhibitor of microsomal triglyceride transfer protein and siRNA directed against apoB Whole article: "PNAS"[ http://www (6.4.2007)
Hormone-based blood pressure pill possible - The Mayo Clinic scientists said the study supports the feasibility of developing a peptide-based drug that can be given in pill form to lower blood pressure and that is based on a hormone originating in the heart, called B-type natriuretic peptide Our formulation of an oral peptide is a technological accomplishment that really can advance the field," said Dr Whole article: www (4.4.2007)
Blood made suitable for all - Scientists have discovered enzymes that can efficiently convert blood groups A, B and AB into the 'universal' O group — which can be given to anyone but is always in short supply The two novel glycosidase enzymes were identified in bacteria by an international team led by Henrik Clausen of the University of Copenhagen in Denmark The ABO blood-type system is based on the presence or absence of the sugar-based antigens 'A' and 'B' on red blood cells Whole article: www (3.4.2007)
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