Date: 2.5.2011
Physiological and pharmacological characterizations of the larval Anopheles albimanus rectum
Millions of people infected and killed from malaria, which is vectored by mosquitoes. In order to control this communicable disease, normally we have to reduce the vector population, so it is critical to understand the process necessary for mosquito survival. Like all aquatic organisms, mosquito larvae have to adapt to a condition that can change significantly in ionic composition. The rectum is the major organ responsible for the regulation of ions in mosquito larvae. It can resorb essential ions and nutrients or excrete excess salts and waste products. The recta differ between mosquito species in structure, also in protein expression etc. however, these have not been characterized extensively.
Researchers from USA investigate the DAR cells (dorsal anterior rectal cells) and non-DAR cells (anterior ventral cells and all posterior cells) in anopheline larvae recta. Proton flux was measured at the basal membrane of larvae treated in varying salinities using self-referencing ion-selective microelectrodes. In addition, some pharmacological inhibitors were applied in these two cell types in the larvae to study the protein function. The results show that the basal membrane proton fluxes differ between DAR cells and non-DAR cells, indicating that protein function changes in different rearing conditions.
Finally, they gave out a model of rectal ion regulation that the non-DAR cells perform the resorptive function in saline water-reared larvae and the secretive function in freshwater-reared larvae. So, it seems may not so effective to reduce the anopheline larvae survival by changing the salinity.
Web-link: http://www.sciencedirect.com/science/article/B6VNH-5023KSG-1/2/d0ee40aebc49a7389861bb19cc6d9179
Keywords: DAR; Ion regulation; ISMs; Mosquito; Self-referencing
Reference: Kristin E. Smith et al. Physiological and pharmacological characterizations of the larval Anopheles albimanus rectum support a change in protein distribution and/or function in varying salinities, Comparative Biochemistry and Physiology - Part A: Molecular & Integrative Physiology, 2010, 157(1):55-62
Gate2Biotech - Biotechnology Portal - All Czech Biotechnology information in one place.
ISSN 1802-2685
This website is maintained by: CREOS CZ
© 2006 - 2024 South Bohemian Agency for Support to Innovative Enterprising (JAIP)
Interesting biotechnology content:
Berkeley - University of California
Environmetal biotechnology - Information about environmetal biotechnology at Wikipedia
Smart soil grows 138% bigger crops using 40% less water
Respiratory bacteria turn off immune system to survive, study finds