Researchers develop a novel dry-powder inhaled vaccine platform

Researchers from the Institute of Process Engineering (IPE) of the Chinese Academy of Sciences have proposed a new "nano-micro composite" delivery concept for vaccines.

Based on this idea, they have developed a single-dose, dry-powder, inhalable vaccine platform using nano-micro composite multilevel structures, which has been successfully prepared in the laboratory, and the vaccine has been shown to be effective in blocking respiratory viral infection and transmission in animal models. This platform holds great promise for combating future emerging and epidemic infectious diseases.

This platform combines biodegradable microspheres with protein nanoparticles. The surface of these nanoparticles can simultaneously display multiple antigens, thus inducing a broad-spectrum immune response and expanding the range of vaccine protection. It also allows for the quick and convenient development of other respiratory virus vaccines due to the flexibility of antigen presentation.

Moreover, the platform's unique nano-micro composite structure enables an efficient immune response in the lungs by facilitating high-performance delivery. Once the antigen-nanoparticles are released, they can be efficiently taken up by antigen-presenting cells.

Additionally, this dry powder vaccine significantly reduces storage and transportation costs, making it suitable for areas with limited refrigeration facilities, thus improving immunization rates.

Zdroj obrázku: IPE, CAS.