Targeting Bacterial Gas Defenses Allow for Increased Efficacy of Numerous Antibiotics

Although scientists have known for centuries that many bacteria produce hydrogen sulfide (H₂S) it was thought to be simply a toxic by-product of cellular activity. Now, researchers at NYU School of Medicine have discovered H₂S in fact plays a major role in protecting bacteria from the effects of numerous different antibiotics.

This information provides the basis for developing new techniques to suppress this universal bacterial defense mechanism and make bacteria more susceptible to antibiotics at lower doses. It also paves the way for reversing antibiotic resistance in human pathogens such as Staphylococcus, Pseudomonas, E. coli, and many others.

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